Abstract
Eur Radiol (2003) 13:729–733
DOI 10.1007/s00330-002-1443-x NUCLEAR MEDICINE
G. Herlin
B. Persson
M. Bergström
B. Långström
P. Aspelin
11C-harmine as a potential PET tracer
for ductal pancreas cancer: in vitro studies
Abstract
Our objective was to find a
tracer in diagnosing human pancreatic
cancer using positron emission tomography
(PET). For this purpose in
vitro test of pancreatic tissues with
autoradiography was used. Autoradiography
was performed with 11C-harmine
(a MAO-A-inhibitor) with and
without competitive inhibition. Tissue
preparations were obtained from
normal human pancreas and pancreatic
cancer. The uptake was compared
with rat brain or pig brain,
tissues with high expression of
MAO-A. Nine autoradiography
studies on 16 samples from five different
human pancreatic cancers gave
a significant level of specific binding
of 11C-harmine in 13, and 3 samples
did not give a significant level of
specific binding of 11C-harmine. All
16 samples were analysed with autoradiography.
Compared with rat
brain, the uptake in the human cancers
varied between 9 and 43% except
for one tissue preparation which
had a too low value for measurement.
This study shows expression of
MAO-A in human pancreatic cancer.
This is readily characterised in vitro.
The potential use of 11C-harmine in
the diagnosis of pancreatic cancer
using PET might be limited, but further
PET studies are necessary.
Keywords Tomography ·
Emission-computed ·
Autoradiography · Harmine ·
Pancreatic neoplasms
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